Today, I had the chance to attend a talk by Michael Fischbach . He presented his group's work on exploring the metabolic abilities of microorganisms, using computational tools to identify operons encoding complex cascades of enzymes - and their chemical products. Dr. Fischbach presented a whirlwind tour of some of the natural products produced by e.g. by the human microbiota and highlighted how little we know about the biosynthetic abilities of even the most widely used microbes. Great presentation and lot's of new science ! Check out the Fischbach lab's recent publications:
- A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA; Cell. 2014 Sep 11;158(6):1402-14. doi: 10.1016/j.cell.2014.08.032.
- Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach MA; Cell. 2014 Jul 17;158(2):412-21. doi: 10.1016/j.cell.2014.06.034.
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